Natural and synthetic prion structure from X-ray fiber diffraction

A conformational isoform of the mammalian prion protein (PrP(Sc)) is the sole component of the infectious pathogen that causes the prion diseases. We have obtained X-ray fiber diffraction patterns from infectious prions that show cross-β diffraction: meridional intensity at 4.8 Å resolution, indicat...

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Detalhes bibliográficos
Main Authors: Wille, Holger, Bian, Wen, McDonald, Michele, Kendall, Amy, Colby, David W., Bloch, Lillian, Ollesch, Julian, Borovinskiy, Alexander L., Cohen, Fred E., Prusiner, Stanley B., Stubbs, Gerald
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761340/
https://ncbi.nlm.nih.gov/pubmed/19805070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909006106
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