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Electron crystallography of the scrapie prion protein complexed with heavy metals

The insolubility of the disease-causing isoform of the prion protein (PrP(Sc)) has prevented studies of its three-dimensional structure at atomic resolution. Electron crystallography of two-dimensional crystals of N-terminally truncated PrP(Sc) (PrP 27–30) and a miniprion (PrP(Sc)106) provided the f...

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Detalhes bibliográficos
Main Authors: Wille, Holger, Govaerts, Cédric, Borovinskiy, Alexander, Latawiec, Diane, Downing, Kenneth H., Cohen, Fred E., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557509/
https://ncbi.nlm.nih.gov/pubmed/17935686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.08.010
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