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Cryo-Immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site

Prion diseases are caused by accumulation of an abnormally folded isoform (PrP(Sc)) of the cellular prion protein (PrP(C)). The subcellular distribution of PrP(Sc) and the site of its formation in brain are still unclear. We performed quantitative cryo-immunogold electron microscopy on hippocampal s...

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書誌詳細
主要な著者: Godsave, Susan F., Wille, Holger, Kujala, Pekka, Latawiec, Diane, DeArmond, Stephen J., Serban, Ana, Prusiner, Stanley B., Peters, Peter J.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2008
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796247/
https://ncbi.nlm.nih.gov/pubmed/19020041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4474-08.2008
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