Cryo-Immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site

Prion diseases are caused by accumulation of an abnormally folded isoform (PrP(Sc)) of the cellular prion protein (PrP(C)). The subcellular distribution of PrP(Sc) and the site of its formation in brain are still unclear. We performed quantitative cryo-immunogold electron microscopy on hippocampal s...

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Hlavní autoři: Godsave, Susan F., Wille, Holger, Kujala, Pekka, Latawiec, Diane, DeArmond, Stephen J., Serban, Ana, Prusiner, Stanley B., Peters, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796247/
https://ncbi.nlm.nih.gov/pubmed/19020041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4474-08.2008
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