Cryo-Immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site

Prion diseases are caused by accumulation of an abnormally folded isoform (PrP(Sc)) of the cellular prion protein (PrP(C)). The subcellular distribution of PrP(Sc) and the site of its formation in brain are still unclear. We performed quantitative cryo-immunogold electron microscopy on hippocampal s...

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Huvudupphovsmän: Godsave, Susan F., Wille, Holger, Kujala, Pekka, Latawiec, Diane, DeArmond, Stephen J., Serban, Ana, Prusiner, Stanley B., Peters, Peter J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2008
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796247/
https://ncbi.nlm.nih.gov/pubmed/19020041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4474-08.2008
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