Prion Uptake in the Gut: Identification of the First Uptake and Replication Sites

After oral exposure, prions are thought to enter Peyer's patches via M cells and accumulate first upon follicular dendritic cells (FDCs) before spreading to the nervous system. How prions are actually initially acquired from the gut lumen is not known. Using high-resolution immunofluorescence a...

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Autori principali: Kujala, Pekka, Raymond, Claudine R., Romeijn, Martijn, Godsave, Susan F., van Kasteren, Sander I., Wille, Holger, Prusiner, Stanley B., Mabbott, Neil A., Peters, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245311/
https://ncbi.nlm.nih.gov/pubmed/22216002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002449
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