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Plasma Membrane Invaginations Containing Clusters of Full-length PrP(Sc) are an Early Form of Prion-associated Neuropathology in vivo

During prion disease cellular prion protein (PrP(C)) is refolded into a pathogenic isoform (PrP(Sc)) that accumulates in the central nervous system and causes neurodegeneration and death. We used immunofluorescence, quantitative cryo-immunogold EM and tomography to detect nascent, full-length PrP(Sc...

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Autors principals: Godsave, Susan F., Wille, Holger, Pierson, Jason, Prusiner, Stanley B., Peters, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596824/
https://ncbi.nlm.nih.gov/pubmed/23481568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.12.015
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