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Plasma Membrane Invaginations Containing Clusters of Full-length PrP(Sc) are an Early Form of Prion-associated Neuropathology in vivo
During prion disease cellular prion protein (PrP(C)) is refolded into a pathogenic isoform (PrP(Sc)) that accumulates in the central nervous system and causes neurodegeneration and death. We used immunofluorescence, quantitative cryo-immunogold EM and tomography to detect nascent, full-length PrP(Sc...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596824/ https://ncbi.nlm.nih.gov/pubmed/23481568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.12.015 |
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