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Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein

Prions are composed solely of an alternatively folded isoform of the prion protein (PrP), designated PrP(Sc). N-terminally truncated PrP(Sc), denoted PrP 27–30, retains infectivity and polymerizes into rods with the ultrastructural and tinctorial properties of amyloid. We report here that some polyo...

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Detalhes bibliográficos
Main Authors: Wille, Holger, Shanmugam, Maheswaran, Murugesu, Muralee, Ollesch, Julian, Stubbs, Gerald, Long, Jeffrey R., Safar, Jiri G., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656150/
https://ncbi.nlm.nih.gov/pubmed/19223590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812770106
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