Chargement en cours...

Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions

Quinacrine is a potent antiprion compound in cell culture models of prion disease but has failed to show efficacy in animal bioassays and human clinical trials. Previous studies demonstrated that quinacrine inefficiently penetrates the blood-brain barrier (BBB), which could contribute to its lack of...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ghaemmaghami, Sina, Ahn, Misol, Lessard, Pierre, Giles, Kurt, Legname, Giuseppe, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777304/
https://ncbi.nlm.nih.gov/pubmed/19956709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000673
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!