Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions

Quinacrine is a potent antiprion compound in cell culture models of prion disease but has failed to show efficacy in animal bioassays and human clinical trials. Previous studies demonstrated that quinacrine inefficiently penetrates the blood-brain barrier (BBB), which could contribute to its lack of...

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Bibliographic Details
Main Authors: Ghaemmaghami, Sina, Ahn, Misol, Lessard, Pierre, Giles, Kurt, Legname, Giuseppe, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777304/
https://ncbi.nlm.nih.gov/pubmed/19956709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000673
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