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Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice
Mice deficient for the cellular prion protein (PrP(C)) do not develop prion disease; accordingly, gene-based strategies to diminish PrP(C) expression are of interest. We synthesized a series of chemically modified antisense oligonucleotides (ASOs) targeted against mouse Prnp messenger RNA (mRNA) and...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381600/ https://ncbi.nlm.nih.gov/pubmed/23344724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2011.6 |
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