Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice

Mice deficient for the cellular prion protein (PrP(C)) do not develop prion disease; accordingly, gene-based strategies to diminish PrP(C) expression are of interest. We synthesized a series of chemically modified antisense oligonucleotides (ASOs) targeted against mouse Prnp messenger RNA (mRNA) and...

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Autors principals: Nazor Friberg, Karah, Hung, Gene, Wancewicz, Ed, Giles, Kurt, Black, Chris, Freier, Sue, Bennett, Frank, DeArmond, Stephen J, Freyman, Yevgeniy, Lessard, Pierre, Ghaemmaghami, Sina, Prusiner, Stanley B
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381600/
https://ncbi.nlm.nih.gov/pubmed/23344724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2011.6
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