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Conformational transformation and selection of synthetic prion strains

The prion protein (PrP) is capable of folding into multiple self-replicating prion strains that produce phenotypically distinct neurological disorders. Although prion strains often breed true upon passage, they can also transform or “mutate” despite being devoid of nucleic acids. To dissect the mech...

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Main Authors: Ghaemmaghami, Sina, Watts, Joel, Nguyen, Hoang-Oanh, Hayashi, Shigenari, DeArmond, Stephen J., Prusiner, Stanley B.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195964/
https://ncbi.nlm.nih.gov/pubmed/21839745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.07.021
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