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Conformational transformation and selection of synthetic prion strains
The prion protein (PrP) is capable of folding into multiple self-replicating prion strains that produce phenotypically distinct neurological disorders. Although prion strains often breed true upon passage, they can also transform or “mutate” despite being devoid of nucleic acids. To dissect the mech...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3195964/ https://ncbi.nlm.nih.gov/pubmed/21839745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.07.021 |
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