Pharmacokinetics of quinacrine in the treatment of prion disease

BACKGROUND: Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrP(Sc). In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrP(C)) to PrP(Sc )at a half-maximal concentration of 300 nM. While these data s...

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Detalhes bibliográficos
Main Authors: Yung, Lotus, Huang, Yong, Lessard, Pierre, Legname, Giuseppe, Lin, Emil T, Baldwin, Michael, Prusiner, Stanley B, Ryou, Chongsuk, Guglielmo, B Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC535929/
https://ncbi.nlm.nih.gov/pubmed/15569390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-4-53
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