Pharmacokinetics of quinacrine in the treatment of prion disease

BACKGROUND: Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrP(Sc). In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrP(C)) to PrP(Sc )at a half-maximal concentration of 300 nM. While these data s...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yung, Lotus, Huang, Yong, Lessard, Pierre, Legname, Giuseppe, Lin, Emil T, Baldwin, Michael, Prusiner, Stanley B, Ryou, Chongsuk, Guglielmo, B Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC535929/
https://ncbi.nlm.nih.gov/pubmed/15569390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-4-53
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky