Pharmacokinetics of Quinacrine Efflux from Mouse Brain via the P-glycoprotein Efflux Transporter

The lipophilic cationic compound quinacrine has been used as an antimalarial drug for over 75 years but its pharmacokinetic profile is limited. Here, we report on the pharmacokinetic properties of quinacrine in mice. Following an oral dose of 40 mg/kg/day for 30 days, quinacrine concentration in the...

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Autori principali: Ahn, Misol, Ghaemmaghami, Sina, Huang, Yong, Phuan, Puay-Wah, May, Barnaby C. H., Giles, Kurt, DeArmond, Stephen J., Prusiner, Stanley B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388068/
https://ncbi.nlm.nih.gov/pubmed/22768295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039112
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