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The peculiar nature of unfolding of the human prion protein
Spontaneous conformational transition of the prion protein from an α-helical isoform to a β-sheet-rich isoform underlies the pathogenesis of sporadic prion diseases. To study the rate-limiting steps of spontaneous conversion, the formation of amyloid fibrils by the recombinant human PrP C-terminal f...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2286731/ https://ncbi.nlm.nih.gov/pubmed/14767078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03457204 |
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