Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes

On passaging synthetic prions, two isolates emerged with incubation times differing by nearly 100 days. Using conformational-stability assays, we determined the guanidine hydrochloride (Gdn·HCl) concentration required to denature 50% of disease-causing prion protein (PrP(Sc)) molecules, denoted as t...

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Bibliografiske detaljer
Main Authors: Legname, Giuseppe, Nguyen, Hoang-Oanh B., Peretz, David, Cohen, Fred E., DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748184/
https://ncbi.nlm.nih.gov/pubmed/17142317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608970103
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