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Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes
On passaging synthetic prions, two isolates emerged with incubation times differing by nearly 100 days. Using conformational-stability assays, we determined the guanidine hydrochloride (Gdn·HCl) concentration required to denature 50% of disease-causing prion protein (PrP(Sc)) molecules, denoted as t...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1748184/ https://ncbi.nlm.nih.gov/pubmed/17142317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608970103 |
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