Truncation of titin’s elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

RATIONALE: The giant protein titin plays key roles in myofilament assembly and determines the passive mechanical properties of the sarcomere. The cardiac titin molecule has two mayor elastic elements, the N2B and the PEVK region. Both have been suggested to determine the elastic properties of the he...

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Bibliografiska uppgifter
Huvudupphovsmän: Granzier, Henk L., Radke, Michael H., Peng, Jun, Westermann, Dirk, Nelson, O. Lynne, Rost, Katharina, King, Nicholas M.P., Yu, Qianli, Tschöpe, Carsten, McNabb, Mark, Larson, Douglas F., Labeit, Siegfried, Gotthardt, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785004/
https://ncbi.nlm.nih.gov/pubmed/19679835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.200964
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