Truncation of titin’s elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

RATIONALE: The giant protein titin plays key roles in myofilament assembly and determines the passive mechanical properties of the sarcomere. The cardiac titin molecule has two mayor elastic elements, the N2B and the PEVK region. Both have been suggested to determine the elastic properties of the he...

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Detalhes bibliográficos
Main Authors: Granzier, Henk L., Radke, Michael H., Peng, Jun, Westermann, Dirk, Nelson, O. Lynne, Rost, Katharina, King, Nicholas M.P., Yu, Qianli, Tschöpe, Carsten, McNabb, Mark, Larson, Douglas F., Labeit, Siegfried, Gotthardt, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785004/
https://ncbi.nlm.nih.gov/pubmed/19679835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.200964
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