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Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy
Titin is a giant protein that is in charge of the assembly and passive mechanical properties of the sarcomere. Cardiac titin contains a unique N2B region, which has been proposed to modulate elasticity of the titin filament and to be important for hypertrophy signaling and the ischemic stress respon...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1805563/ https://ncbi.nlm.nih.gov/pubmed/17360664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608543104 |
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