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Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

Titin is a giant protein that is in charge of the assembly and passive mechanical properties of the sarcomere. Cardiac titin contains a unique N2B region, which has been proposed to modulate elasticity of the titin filament and to be important for hypertrophy signaling and the ischemic stress respon...

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Detalhes bibliográficos
Main Authors: Radke, Michael H., Peng, Jun, Wu, Yiming, McNabb, Mark, Nelson, O. Lynne, Granzier, Henk, Gotthardt, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805563/
https://ncbi.nlm.nih.gov/pubmed/17360664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608543104
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