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Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

ABSTRACT: Impaired diastolic filling is a main contributor to heart failure with preserved ejection fraction (HFpEF), a syndrome with increasing prevalence and no treatment. Both collagen and the giant sarcomeric protein titin determine diastolic function. Since titin’s elastic properties can be adj...

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Detalhes bibliográficos
Publicado no:J Mol Med (Berl)
Main Authors: Hinze, Florian, Dieterich, Christoph, Radke, Michael H., Granzier, Henk, Gotthardt, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143357/
https://ncbi.nlm.nih.gov/pubmed/27889803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-016-1483-3
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