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EXPERIMENTALLY INCREASING TITIN’S COMPLIANCE THROUGH RBM20 INHIBITION IMPROVES DIASTOLIC FUNCTION IN A MOUSE MODEL OF HFpEF
BACKGROUND: Left Ventricular (LV) stiffening contributes to Heart Failure with preserved Ejection Fraction (HFpEF), a syndrome with no effective treatment options. Increasing titin’s compliance in the heart has become possible recently through inhibition of the splicing factor RBM20. Here we investi...
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| Udgivet i: | Circulation |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5069184/ https://ncbi.nlm.nih.gov/pubmed/27630136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.023003 |
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