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EXPERIMENTALLY INCREASING TITIN’S COMPLIANCE THROUGH RBM20 INHIBITION IMPROVES DIASTOLIC FUNCTION IN A MOUSE MODEL OF HFpEF

BACKGROUND: Left Ventricular (LV) stiffening contributes to Heart Failure with preserved Ejection Fraction (HFpEF), a syndrome with no effective treatment options. Increasing titin’s compliance in the heart has become possible recently through inhibition of the splicing factor RBM20. Here we investi...

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Bibliografiske detaljer
Udgivet i:Circulation
Main Authors: Methawasin, Mei, Strom, Joshua G, Slater, Rebecca E, Fernandez, Vanessa, Saripalli, Chandra, Granzier, Henk
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069184/
https://ncbi.nlm.nih.gov/pubmed/27630136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.023003
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