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Alternative Splicing of Titin Restores Diastolic Function in a HFpEF-like Genetic Murine Model (Ttn(ΔIAjxn))
RATIONALE: HFpEF patients experience elevated filling pressures and reduced ventricular compliance. The splicing factor RBM20 regulates the contour length of titin’s spring region and thereby determines the passive stiffness of cardiomyocytes. Inhibition of RBM20 leads to super compliant titin isofo...
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| Publicado no: | Circ Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5059842/ https://ncbi.nlm.nih.gov/pubmed/27470639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308904 |
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