Titin-Actin Interaction: PEVK-Actin-Based Viscosity in a Large Animal

Titin exhibits an interaction between its PEVK segment and the actin filament resulting in viscosity, a speed dependent resistive force, which significantly influences diastolic filling in mice. While diastolic disease is clinically pervasive, humans express a more compliant titin (N2BA:N2B ratio ~0...

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Detalhes bibliográficos
Main Authors: Chung, Charles S., Bogomolovas, Julius, Gasch, Alexander, Hidalgo, Carlos G., Labeit, Siegfried, Granzier, Henk L.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227466/
https://ncbi.nlm.nih.gov/pubmed/22162634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/310791
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