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Single Molecule Force Spectroscopy of the Cardiac Titin N2B Element: EFFECTS OF THE MOLECULAR CHAPERONE αB-CRYSTALLIN WITH DISEASE-CAUSING MUTATIONS

The small heat shock protein αB-crystallin interacts with N2B-Us, a large unique sequence found in the N2B element of cardiac titin. Using single molecule force spectroscopy, we studied the effect of αB-crystallin on the N2B-Us and its flanking Ig-like domains. Ig domains from the proximal tandem Ig...

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Detalles Bibliográficos
Main Authors: Zhu, Yi, Bogomolovas, Julius, Labeit, Siegfried, Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679491/
https://ncbi.nlm.nih.gov/pubmed/19282282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809743200
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