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PKC phosphorylation of titin's PEVK element-- a novel and conserved pathway for modulating myocardial stiffness

RATIONALE: Protein Kinase C (PKC) regulates contractility of cardiac muscle cells by phosphorylating thin- and thick- filament based proteins. Myocardial sarcomeres also contain a third myofilament, titin, and it is unknown whether titin can be phosphorylated by PKC and if it affects passive tension...

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Detalhes bibliográficos
Main Authors: Hidalgo, Carlos, Hudson, Bryan, Bogomolovas, Julius, Zhu, Yi, Anderson, Brian, Greaser, Marion, Labeit, Siegfried, Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764991/
https://ncbi.nlm.nih.gov/pubmed/19679839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.198465
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