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Titin Based Viscosity in Ventricular Physiology: An Integrative Investigation of PEVK-Actin Interactions

Viscosity is proposed to modulate diastolic function, but only limited understanding of the source(s) of viscosity exists. In-vitro experiments have shown that the proline-glutamic acid-valine-lysine (PEVK) rich element of titin interacts with actin, causing a viscous force in the sarcomere. It is u...

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Detalhes bibliográficos
Main Authors: Chung, Charles S, Methawasin, Methajit, Nelson, O Lynne, Radke, Michael H, Hidalgo, Carlos G, Gotthardt, Michael, Granzier, Henk L
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150406/
https://ncbi.nlm.nih.gov/pubmed/21708170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.06.006
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