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Mechanism for CCC DNA Synthesis in Hepadnaviruses

Hepadnavirus replication requires the synthesis of a covalently closed circular (CCC) DNA from the relaxed circular (RC) viral genome by an unknown mechanism. CCC DNA formation could require enzymatic activities of the viral reverse transcriptase (RT), or cellular DNA repair enzymes, or both. Physic...

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Détails bibliographiques
Auteurs principaux: Sohn, Ji A., Litwin, Samuel, Seeger, Christoph
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778999/
https://ncbi.nlm.nih.gov/pubmed/19956651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008093
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