Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of infected hepatocyte and serves as the transcriptional template for viral mRNA synthesis. Elimination of cccDNA is the prerequisite for either a therapeutic cure or immunological resolutio...

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Detalhes bibliográficos
Main Authors: Liu, Fei, Campagna, Matthew, Qi, Yonghe, Zhao, Xuesen, Guo, Fang, Xu, Chunxiao, Li, Sichen, Li, Wenhui, Block, Timothy M., Chang, Jinhong, Guo, Ju-Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771898/
https://ncbi.nlm.nih.gov/pubmed/24068929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003613
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