IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA

BACKGROUND: Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, displaying succinyltransferase activity, is recruited onto cccDNA to modulate H...

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Bibliografske podrobnosti
izdano v:Clin Epigenetics
Main Authors: Yuan, Ying, Yuan, Hongfeng, Yang, Guang, Yun, Haolin, Zhao, Man, Liu, Zixian, Zhao, Lina, Geng, Yu, Liu, Lei, Wang, Jiapei, Zhang, Huihui, Wang, Yufei, Zhang, Xiao-dong
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487718/
https://ncbi.nlm.nih.gov/pubmed/32894195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00928-z
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