Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs

Chronic Hepatitis B Virus (HBV) infection is generally not curable with current anti-viral drugs. Virus rebounds after stopping treatment from the stable HBV covalently-closed-circular DNA (cccDNA). The development of drugs that directly target cccDNA is hampered by the lack of robust HBV cccDNA mod...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Li, Feng, Cheng, Liang, Murphy, Christopher M., Reszka-Blanco, Natalia J., Wu, Yaxu, Chi, Liqun, Hu, Jianming, Su, Lishan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098228/
https://ncbi.nlm.nih.gov/pubmed/27819342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36483
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items