The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely

HBV covalently closed circular DNA (cccDNA) is drug-resistant and responsible for viral persistence. To facilitate the development of anti-cccDNA drugs, we developed a minicircle DNA vector (MC)-based technology to produce large quantity of recombined cccDNA (rcccDNA) resembling closely to its wild-...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Guo, Xiaoyan, Chen, Ping, Hou, Xiaohu, Xu, Wenjuan, Wang, Dan, Wang, Tian-yan, Zhang, Liping, Zheng, Gang, Gao, Zhi-liang, He, Cheng-Yi, Zhou, Boping, Chen, Zhi-Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865889/
https://ncbi.nlm.nih.gov/pubmed/27174254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25552
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