Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins. Using a cccDNA-specific chromatin immunoprecipitation (ChIP)-based quantitative assa...

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Detalhes bibliográficos
Main Authors: Belloni, Laura, Pollicino, Teresa, De Nicola, Francesca, Guerrieri, Francesca, Raffa, Giuseppina, Fanciulli, Maurizio, Raimondo, Giovanni, Levrero, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775998/
https://ncbi.nlm.nih.gov/pubmed/19906987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908365106
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