IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome

The HBV covalently closed circular DNA (cccDNA) is organized as a mini-chromosome in the nuclei of infected hepatocytes by histone and non-histone proteins. Transcription from the cccDNA of the RNA replicative intermediate termed pre-genome (pgRNA), is the critical step for genome amplification and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Palumbo, Gianna Aurora, Scisciani, Cecilia, Pediconi, Natalia, Lupacchini, Leonardo, Alfalate, Dulce, Guerrieri, Francesca, Calvo, Ludovica, Salerno, Debora, Di Cocco, Silvia, Levrero, Massimo, Belloni, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651563/
https://ncbi.nlm.nih.gov/pubmed/26580974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142599
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