Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins. Using a cccDNA-specific chromatin immunoprecipitation (ChIP)-based quantitative assa...

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Main Authors: Belloni, Laura, Pollicino, Teresa, De Nicola, Francesca, Guerrieri, Francesca, Raffa, Giuseppina, Fanciulli, Maurizio, Raimondo, Giovanni, Levrero, Massimo
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2009
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775998/
https://ncbi.nlm.nih.gov/pubmed/19906987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908365106
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