Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of infected hepatocyte and serves as the transcriptional template for viral mRNA synthesis. Elimination of cccDNA is the prerequisite for either a therapeutic cure or immunological resolutio...

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Autori principali: Liu, Fei, Campagna, Matthew, Qi, Yonghe, Zhao, Xuesen, Guo, Fang, Xu, Chunxiao, Li, Sichen, Li, Wenhui, Block, Timothy M., Chang, Jinhong, Guo, Ju-Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771898/
https://ncbi.nlm.nih.gov/pubmed/24068929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003613
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