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Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA
Hepatitis B virus (HBV) causes chronic infections that cannot yet be cured. The virus persists in infected hepatocytes, because covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is stable in nondividing cells. Antiviral therapies with nucleoside analogues inh...
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| I publikationen: | Mol Ther |
|---|---|
| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5088770/ https://ncbi.nlm.nih.gov/pubmed/27203444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.94 |
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