Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9

Chronic hepatitis B is a severe liver disease caused by hepatitis B virus (HBV) infection. Covalently closed circular DNA (cccDNA), a super-spiralized, double-stranded form of the HBV genome, is the major determinant of viral persistence. CRISPR/Cas9 nucleases have been recently shown to introduce d...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kostyushev, Dmitry, Kostyusheva, Anastasiya, Brezgin, Sergey, Zarifyan, Dmitry, Utkina, Anastasiya, Goptar, Irina, Chulanov, Vladimir
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372644/
https://ncbi.nlm.nih.gov/pubmed/30755668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38526-6
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