Clearing of Foreign Episomal DNA from Human Cells by CRISPRa-Mediated Activation of Cytidine Deaminases

Restriction of foreign DNA is a fundamental defense mechanism required for maintaining genomic stability and proper function of mammalian cells. APOBEC cytidine deaminases are crucial effector molecules involved in clearing pathogenic DNA of viruses and other microorganisms and improperly localized...

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Publicado en:Int J Mol Sci
Main Authors: Brezgin, Sergey, Kostyusheva, Anastasiya, Ponomareva, Natalia, Volia, Viktoriia, Goptar, Irina, Nikiforova, Anastasiya, Shilovskiy, Igor, Smirnov, Valery, Kostyushev, Dmitry, Chulanov, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557733/
https://ncbi.nlm.nih.gov/pubmed/32962129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186865
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