Clearing of Foreign Episomal DNA from Human Cells by CRISPRa-Mediated Activation of Cytidine Deaminases

Restriction of foreign DNA is a fundamental defense mechanism required for maintaining genomic stability and proper function of mammalian cells. APOBEC cytidine deaminases are crucial effector molecules involved in clearing pathogenic DNA of viruses and other microorganisms and improperly localized...

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Pubblicato in:Int J Mol Sci
Autori principali: Brezgin, Sergey, Kostyusheva, Anastasiya, Ponomareva, Natalia, Volia, Viktoriia, Goptar, Irina, Nikiforova, Anastasiya, Shilovskiy, Igor, Smirnov, Valery, Kostyushev, Dmitry, Chulanov, Vladimir
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557733/
https://ncbi.nlm.nih.gov/pubmed/32962129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186865
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