Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

Background: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is the major cause of viral persistence in patients with chronic HBV infection. Understanding the mechanisms underlying stability and persistence of HBV cccDNA in hepatocytes is critical for developing novel therapeutics...

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Publicado no:Microorganisms
Main Authors: Brezgin, Sergey, Kostyusheva, Anastasiia, Bayurova, Ekaterina, Gordeychuk, Ilya, Isaguliants, Maria, Goptar, Irina, Nikiforova, Anastasiia, Smirnov, Valery, Volchkova, Elena, Glebe, Dieter, Kostyushev, Dmitry, Chulanov, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920784/
https://ncbi.nlm.nih.gov/pubmed/31698767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms7110533
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