Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

Background: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is the major cause of viral persistence in patients with chronic HBV infection. Understanding the mechanisms underlying stability and persistence of HBV cccDNA in hepatocytes is critical for developing novel therapeutics...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Microorganisms
Prif Awduron: Brezgin, Sergey, Kostyusheva, Anastasiia, Bayurova, Ekaterina, Gordeychuk, Ilya, Isaguliants, Maria, Goptar, Irina, Nikiforova, Anastasiia, Smirnov, Valery, Volchkova, Elena, Glebe, Dieter, Kostyushev, Dmitry, Chulanov, Vladimir
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920784/
https://ncbi.nlm.nih.gov/pubmed/31698767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms7110533
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