Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain : Implication for Alzheimer’s Disease

Recent studies have suggested a possible role of insulin dysfunction in the pathogenesis of sporadic Alzheimer’s disease (AD). In AD, brain glucose metabolism is impaired, and this impairment appears to precede the pathology and clinical symptoms of the disease. However, the exact contribution of im...

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Bibliografiska uppgifter
Huvudupphovsmän: Deng, Yanqiu, Li, Bin, Liu, Ying, Iqbal, Khalid, Grundke-Iqbal, Inge, Gong, Cheng-Xin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2009
Ämnen:
Regular Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774072/
https://ncbi.nlm.nih.gov/pubmed/19815707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090157
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