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Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain : Implication for Alzheimer’s Disease

Recent studies have suggested a possible role of insulin dysfunction in the pathogenesis of sporadic Alzheimer’s disease (AD). In AD, brain glucose metabolism is impaired, and this impairment appears to precede the pathology and clinical symptoms of the disease. However, the exact contribution of im...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Deng, Yanqiu, Li, Bin, Liu, Ying, Iqbal, Khalid, Grundke-Iqbal, Inge, Gong, Cheng-Xin
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Investigative Pathology 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774072/
https://ncbi.nlm.nih.gov/pubmed/19815707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090157
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