O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of individuals with Alzheimer's disease (AD) and other tauopathies. Tau pathology is critical to pathogenesis and correlates to the severity of dementia. However, the mecha...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Liu, Fei, Iqbal, Khalid, Grundke-Iqbal, Inge, Hart, Gerald W., Gong, Cheng-Xin
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC490015/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15249677/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400348101
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