O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of individuals with Alzheimer's disease (AD) and other tauopathies. Tau pathology is critical to pathogenesis and correlates to the severity of dementia. However, the mecha...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Liu, Fei, Iqbal, Khalid, Grundke-Iqbal, Inge, Hart, Gerald W., Gong, Cheng-Xin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2004
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC490015/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15249677/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400348101
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