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Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain : Implication for Alzheimer’s Disease

Recent studies have suggested a possible role of insulin dysfunction in the pathogenesis of sporadic Alzheimer’s disease (AD). In AD, brain glucose metabolism is impaired, and this impairment appears to precede the pathology and clinical symptoms of the disease. However, the exact contribution of im...

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書誌詳細
主要な著者: Deng, Yanqiu, Li, Bin, Liu, Ying, Iqbal, Khalid, Grundke-Iqbal, Inge, Gong, Cheng-Xin
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Investigative Pathology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774072/
https://ncbi.nlm.nih.gov/pubmed/19815707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090157
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