Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic Aβ Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

The accumulation of amyloid-β (Aβ) peptides in the brain of patients with Alzheimer's disease (AD) may arise from an imbalance between Aβ production and clearance. Overexpression of the Aβ-degrading enzyme neprilysin in brains of human amyloid precursor protein (hAPP) transgenic mice decreases...

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Main Authors: Meilandt, William J., Cisse, Moustapha, Ho, Kaitlyn, Wu, Tiffany, Esposito, Luke A., Scearce-Levie, Kimberly, Cheng, Irene H., Yu, Gui-Qiu, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768427/
https://ncbi.nlm.nih.gov/pubmed/19228952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2984-08.2009
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