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Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice

Alzheimer's disease (AD) is associated with accumulations of amyloid-β (Aβ) peptides, oxidative damage, mitochondrial dysfunction, neurodegeneration, and dementia. The mitochondrial antioxidant manganese superoxide dismutase-2 (Sod2) might protect against these alterations. To test this hypothe...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Esposito, Luke, Raber, Jacob, Kekonius, Lisa, Yan, Fengrong, Yu, Giu-Qiu, Bien-Ly, Nga, Puoliväli, Jukka, Scearce-Levie, Kimberly, Masliah, Eliezer, Mucke, Lennart
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674260/
https://ncbi.nlm.nih.gov/pubmed/16687508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0482-06.2006
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