Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1β (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns (DAMPs), and crystals. Inappropriate Cryopyrin activi...

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Autores principales: Lamkanfi, Mohamed, Mueller, James L., Vitari, Alberto C., Misaghi, Shahram, Fedorova, Anna, Deshayes, Kurt, Lee, Wyne P., Hoffman, Hal M., Dixit, Vishva M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2009
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762099/
https://ncbi.nlm.nih.gov/pubmed/19805629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200903124
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