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Role of the Leucine-rich Repeat (LRR) Domain of Cryopyrin/NALP3 in Monosodium Urate Crystal-induced Inflammation
OBJECTIVES: The mechanism by which MSU crystals intracellularly activate the Cryopyrin inflammasome is unknown. Here, we used a mouse molecular genetics-based approach to test if the LRR domain of Cyopyrin is required for MSU crystal-induced inflammation. METHODS: Cryopyrin knockout lacZ (Cryo(−Z/−Z...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929807/ https://ncbi.nlm.nih.gov/pubmed/20506351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27456 |
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