Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

BACKGROUND: Monogenic autoinflammatory disorders are characterized by dysregulation of the innate immune system, for example by gain-of-function mutations in inflammasome-forming proteins, such as NOD-like receptor family CARD-containing 4 protein (NLRC4). OBJECTIVE: Here we investigate the mechanis...

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Udgivet i:J Allergy Clin Immunol
Main Authors: Moghaddas, Fiona, Zeng, Ping, Zhang, Yuxia, Schützle, Heike, Brenner, Sebastian, Hofmann, Sigrun R., Berner, Reinhard, Zhao, Yuanbo, Lu, Bingtai, Chen, Xiaoyun, Zhang, Li, Cheng, Suyun, Winkler, Stefan, Lehmberg, Kai, Canna, Scott W., Czabotar, Peter E., Wicks, Ian P., De Nardo, Dominic, Hedrich, Christian M., Zeng, Huasong, Masters, Seth L.
Format: Artigo
Sprog:Inglês
Udgivet: Mosby 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281029/
https://ncbi.nlm.nih.gov/pubmed/29778503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.04.033
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