Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

BACKGROUND: Monogenic autoinflammatory disorders are characterized by dysregulation of the innate immune system, for example by gain-of-function mutations in inflammasome-forming proteins, such as NOD-like receptor family CARD-containing 4 protein (NLRC4). OBJECTIVE: Here we investigate the mechanis...

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Publicado no:J Allergy Clin Immunol
Main Authors: Moghaddas, Fiona, Zeng, Ping, Zhang, Yuxia, Schützle, Heike, Brenner, Sebastian, Hofmann, Sigrun R., Berner, Reinhard, Zhao, Yuanbo, Lu, Bingtai, Chen, Xiaoyun, Zhang, Li, Cheng, Suyun, Winkler, Stefan, Lehmberg, Kai, Canna, Scott W., Czabotar, Peter E., Wicks, Ian P., De Nardo, Dominic, Hedrich, Christian M., Zeng, Huasong, Masters, Seth L.
Formato: Artigo
Idioma:Inglês
Publicado em: Mosby 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281029/
https://ncbi.nlm.nih.gov/pubmed/29778503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.04.033
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