Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

BACKGROUND: Monogenic autoinflammatory disorders are characterized by dysregulation of the innate immune system, for example by gain-of-function mutations in inflammasome-forming proteins, such as NOD-like receptor family CARD-containing 4 protein (NLRC4). OBJECTIVE: Here we investigate the mechanis...

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Publicat a:J Allergy Clin Immunol
Autors principals: Moghaddas, Fiona, Zeng, Ping, Zhang, Yuxia, Schützle, Heike, Brenner, Sebastian, Hofmann, Sigrun R., Berner, Reinhard, Zhao, Yuanbo, Lu, Bingtai, Chen, Xiaoyun, Zhang, Li, Cheng, Suyun, Winkler, Stefan, Lehmberg, Kai, Canna, Scott W., Czabotar, Peter E., Wicks, Ian P., De Nardo, Dominic, Hedrich, Christian M., Zeng, Huasong, Masters, Seth L.
Format: Artigo
Idioma:Inglês
Publicat: Mosby 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281029/
https://ncbi.nlm.nih.gov/pubmed/29778503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.04.033
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