Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response

ATM and ATR protein kinases play a crucial role in cellular DNA damage responses. The inhibition of ATM and ATR can lead to the abolition of the function of cell cycle checkpoints. In this regard, it is expected that checkpoint inhibitors can serve as sensitizing agents for anti-cancer chemo/radioth...

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Detalhes bibliográficos
Main Authors: Nishida, Hiroshi, Tatewaki, Naoto, Nakajima, Yuki, Magara, Taku, Ko, Kam Ming, Hamamori, Yasuo, Konishi, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761266/
https://ncbi.nlm.nih.gov/pubmed/19625493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp593
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